The key ingredients are listed below:

Saffron Extract: The same high-grade Persian strain studied at Tehran University of Medical Sciences. Twenty-three double-blind randomized clinical trials evaluated the effectiveness of saffron or its main components against neurocognitive disorders, with a meta-analysis reporting statistically significant associations between saffron supplementation and cognitive performance measures. Crocin and crocetin possess neuroprotective effects through reduction of oxidative stress, neuroinflammation, blood-brain barrier damage, and nerve cell apoptosis, and exert neuroprotection through decrease in Aβ accumulation and synaptic loss.

Fucoxanthin: One of the rare natural compounds proven to cross the blood-brain barrier. Fucoxanthin was reported to penetrate the blood-brain barrier, and was superior to other carotenoids to exert anti-neurodegenerative disorder effects via acting on multiple targets, including amyloid protein aggregation, oxidative stress, neuroinflammation, neuronal loss, neurotransmission dysregulation and gut microbiota disorder. Research found that fucoxanthin improved neurological dysfunction, reduced brain edema, attenuated cortical lesion volume, and decreased dendrites loss; fucoxanthin suppressed blood-brain barrier leakage and preserved tight junction proteins.

Fucoidan: Published in Neural Regeneration Research to support the growth of new neural connections. Fucoidan has risen to prominence as one of the most promising neuroprotective agents obtained from macroalgae, with the neuroprotective effect related to oxidative stress, mitochondrial function, neuroinflammation, apoptosis, and the interaction between gut-brain-microbiota. A 2026 study examining fucoidan’s neuroprotective effects found it serves as a P-selectin blocker with anti-inflammatory and antioxidant properties.

Oleuropein: The reason Mediterranean diets support the brain — shown to clear toxic protein buildups and reduce oxidative stress in brain tissue by up to 40%, according to MemoVolt’s product page references.

Berberine HCl: Activates AMPK — the metabolic master switch — helping brain cells restore their ability to absorb glucose. Berberine is the only botanical included in European guidelines for the management of dyslipidemia and has extensive published research for metabolic function, insulin sensitivity, and AMPK activation.

Ceylon Cinnamon Bark: Research from the Human Nutrition Research Center found Ceylon Cinnamon improves insulin receptor sensitivity by up to 20%, working synergistically with Berberine to improve the metabolic environment of brain cells. A 2025 randomized clinical trial confirmed the Berberine + Cinnamon combination significantly reduced LDL-C and improved metabolic markers.

Corosolic Acid: Activates GLUT4 glucose transporters — the molecular doorways through which glucose enters cells. Corosolic acid’s mechanism is insulin-independent, providing a secondary pathway for glucose to enter brain cells even when insulin signaling is impaired.

Kudzu Flower Extract: Research from Sichuan University found its isoflavones improve glucose uptake in brain tissue specifically — targeting exactly the areas which need maximum fuel support for cognitive function.

Morosil: The hero ingredient. Produced exclusively from Moro oranges grown in volcanic soil at the base of Mount Etna — a unique agricultural microenvironment. Clinically shown to reduce inflammatory markers while improving metabolic function, and it enhances the bioavailability of every other ingredient in the formula — making the entire formula more effective than any of its individual components alone.

Xylitol: A natural sugar alcohol that provides clean fuel without spiking blood sugar, supporting the brain while the other ingredients support normal glucose processing. Xylitol has also been associated with antimicrobial and anti-inflammatory properties in published research.