The key ingredients are listed below:

Berberine HCL
The formula’s most extensively research-validated ingredient for cholesterol management. Berberine is the only botanical compound included in European guidelines for the management of dyslipidemia. A meta-analysis of 16 randomized clinical trials with 2,147 participants found that Berberine significantly reduced total cholesterol (MD = −0.47 mmol/L), LDL cholesterol (MD = −0.38 mmol/L), and triglycerides (MD = −0.28 mmol/L), while increasing HDL cholesterol (MD = +0.08 mmol/L) — with satisfactory safety and no severe adverse events.

The most recent clinical evidence is extraordinary. A randomized placebo-controlled trial published in JACC: Asia (June 2026) found that after 12 weeks, Berberine 500mg twice daily reduced apolipoprotein B by −1.18 SD, total cholesterol by −1.15 SD, LDL cholesterol by −1.06 SD, and triglycerides by −0.77 SD — supporting Berberine as a complementary treatment for atherogenic lipids, with greater efficacy in women than in men.

Bitter Melon Extract (Momordica charantia)
A well-studied traditional botanical with documented effects on both glucose and lipid metabolism. Bitter Melon contains at least three active compounds with anti-diabetic and lipid-modulating properties: charantin, vicine, and polypeptide-p. Research has documented Bitter Melon’s ability to reduce LDL cholesterol and support glucose metabolism — making it particularly relevant for the metabolic-cardiovascular connection that ColestZen targets.

Cinnamon Bark Extract
A randomized clinical trial published in a European Journal of Nutrition research letter (February 2025) found that twelve weeks of Berberine plus Cinnamon supplementation significantly reduced fasting blood sugar (p = 0.031), HbA1c (p = 0.013), and LDL-C concentration (p = 0.039) in patients with type 2 diabetes — validating the specific Berberine-Cinnamon combination present in ColestZen’s formula. Cinnamon’s polyphenols and procyanidins inhibit intestinal glucose absorption and slow carbohydrate digestion, reducing postprandial lipid spikes.

Green Tea Leaf Extract (EGCG)
Green Tea’s catechins — particularly EGCG — have documented cardiovascular protective effects through multiple mechanisms: inhibiting LDL oxidation (which makes LDL particles more dangerous to arterial walls), reducing systemic inflammation, supporting endothelial function, and modestly improving the lipid profile. The anti-inflammatory dimension is particularly important: in a double-blind, randomized, placebo-controlled trial, supplementation significantly decreased high-sensitivity C-reactive protein (−30.8%) and interleukin-6 (−25.0%) — inflammatory markers directly linked to cardiovascular event risk.

Chromium Picolinate
An essential trace mineral with established roles in both glucose and lipid metabolism. Chromium’s enhancement of insulin sensitivity through Akt phosphorylation creates a more efficient metabolic environment in which the liver processes lipids more effectively — supporting healthier triglyceride levels and reducing the hepatic overproduction of VLDL cholesterol. Research specifically examining chromium’s lipid effects has found associations with improved triglyceride levels and lipid ratios in supplemented populations.

Banaba Leaf Extract (Lagerstroemia speciosa)
Banaba Leaf’s corosolic acid supports glucose transport into cells through GLUT4 activation — an insulin-independent pathway that improves cellular glucose utilization and reduces the hyperglycemia that contributes to dyslipidemia. Research published in peer-reviewed journals has documented corosolic acid’s effects on both glucose homeostasis and downstream lipid metabolism markers, making it a meaningful complement to the formula’s primary cholesterol-targeting ingredients.