The key ingredients are listed below:

Green Tea Leaf Extract: The formula’s most cochlear-specific ingredient from a research standpoint. Research has demonstrated that EGCG (epigallocatechin gallate) can protect cochlear hair cells from ototoxic drug damage. EGCG inhibits γ-secretase activity to suppress Notch signaling pathway and promotes the proliferation and regeneration of hair cells in the damaged cochlea. EGCG has been demonstrated to prevent hair cell loss in the organ of Corti by inhibiting NF-κB and caspase-3 activity, and has shown promise in promoting hearing recovery by increasing neural stem cell proliferation and differentiation. EGCG boasts greater antioxidant activity than Vitamin C, demonstrating the ability to reduce oxidative stress levels — a primary driver of age-related cochlear hair cell degradation.

Ginseng Root Extract: One of the most extensively studied herbal ingredients in the world, with documented relevance to both cognitive function and auditory health. In clinical studies, Panax ginseng has demonstrated improved hearing thresholds in patients with sensorineural hearing loss and alleviated the symptoms of tinnitus. A 14-day study in textile workers found that ginseng provided defense against noise-induced temporary threshold shifts. Ginsenoside Rc from Panax ginseng has been examined for protection of cochlear cells from oxidative stress and inflammatory damage — among the most common causes of cochlear hair cell death. Additionally, ginseng’s neuroprotective and cognitive-alertness benefits are well-documented in the broader published literature.

Maca Root Extract: According to AudiLeaf’s product page, Maca Root is included for its natural adaptogenic properties and its potential to support energy, stamina, and mental clarity while promoting healthy nerve and auditory function. Maca’s adaptogenic properties support stress resilience, which research links to auditory processing quality. Research has found maca consumption associated with improvements in self-reported energy and mood, and its non-hormonal mechanism makes it well-tolerated for long-term daily use.

African Mango Seed Extract: The brand describes African Mango Seed Extract as being packed with antioxidants and essential fatty acids that help maintain circulatory and nerve health, ensuring optimal oxygen flow to the auditory system. The cochlea requires consistent blood flow to deliver oxygen and nutrients to its delicate hair cells — and antioxidant-rich compounds that support circulatory integrity are directly relevant to this requirement. African Mango’s antioxidant properties are documented in laboratory research.

Guarana Seed Extract: The product page describes Guarana as providing a natural energy boost that helps improve circulation to the ears and brain. Guarana contains naturally occurring caffeine and other xanthines that provide documented cognitive-enhancing and energizing properties. Research published in Pharmacology, Biochemistry and Behavior found guarana supplementation associated with improved attention, memory, and alertness. Note: Guarana contains caffeine, which may interact with certain medications.

Grapefruit Seed Extract: According to the brand, Grapefruit Seed Extract is rich in bioflavonoids and supports immune balance and cellular protection while aiding in detoxifying the body and reducing inflammation that can impact hearing clarity. Grapefruit seed extract contains bioflavonoids with documented antioxidant properties. However, this ingredient comes with an important safety note: grapefruit-derived products can interact with numerous prescription medications through CYP3A4 enzyme pathways. Anyone taking prescription medications should consult their physician before using any supplement containing grapefruit-derived ingredients.