The key ingredients are listed below:

Chromium Picolinate: An essential trace mineral with a documented role in glucose metabolism. Chromium functions as a co-factor for insulin through Akt phosphorylation, supporting efficient glucose processing. Since the brain depends on a consistent glucose supply for all cognitive functions, chromium’s metabolic role provides an indirect but meaningful contribution to cognitive energy stability. Chromium has a documented nutritional role in metabolism, notably the processing of major nutrients.

Guarana Seed Extract: The formula’s most directly validated ingredient for cognitive performance. Multiple active ingredients are found in guarana including caffeine, theobromine, saponins, tannins, and catechin monomers. Several double-blind, placebo-controlled, cross-over clinical studies demonstrate that guarana extract improved memory, attention, cognitive speed, focus, alertness, mental acuity and mood over at least six hours — with effects unlikely to be due to caffeine content alone.

Green Tea Extract: Green tea and its main ingredients, EGCG and L-theanine, can improve cognitive, neuropsychological, and other brain functions. Research results suggest long-term benefits include improved mental facilities, a more relaxed mood, and a lower risk of dementia. Green tea extract also increases the brain’s effective connectivity, leading to improvement in working memory performance in clinical research.

Panax Ginseng: One of the most studied herbal ingredients for cognitive function. A major clinical study found Ginseng to be effective in 2,506 subjects for working memory support, and American ginseng was described to improve working memory and calmness in people. Ginseng’s ginsenosides support cerebrovascular circulation, reduce neuroinflammation, and modulate neurotransmitter systems relevant to memory and learning.

Grape Seed Extract: One of the most potent natural sources of oligomeric proanthocyanidins (OPCs) — antioxidant compounds with documented ability to cross the blood-brain barrier. Grape Seed Extract’s OPCs neutralize free radicals in neural tissue, reduce neuroinflammation, and support cerebrovascular health — providing direct neuroprotective coverage against the oxidative damage that accelerates cognitive aging.

Maca Root: A well-documented adaptogenic superfood with multiple published studies on energy regulation, hormonal balance, and stress resilience. Maca acts on the HPA (hypothalamic-pituitary-adrenal) axis to regulate cortisol responses, contributing to the reduced mental fatigue and cognitive interference that chronic stress produces.

Eleuthero: Also known as Siberian Ginseng — one of the most extensively studied adaptogens in clinical research. Eleuthero’s eleutherosides support the body’s resistance to mental and physical stress, reduce fatigue, and support sustained mental performance under demanding conditions.

Astragalus Root: A traditional adaptogenic herb with documented immunomodulatory, anti-fatigue, and anti-inflammatory properties. Astragalus supports mitochondrial function and cellular energy production, contributing to the cognitive energy reserves that focused thinking requires.

African Mango: Contributes metabolic support through its documented effects on adiponectin and leptin — hormones that influence both metabolic efficiency and neurological function. Stable metabolic markers contribute to more consistent energy availability for brain cells.